Topical/Transdermal delivery systems

Topical/Transdermal delivery systems
        Topical and transdermal delivery is concerned with the delivery of actives to the skin for local effects or across the skin for systemic therapy, respectively. Delivery of actives into/through the skin is an important alternative route to the other routes of administration for example oral or intravenous routes. Several benefits of the skin delivery include avoidance of irritation to the gastrointestinal tract, circumvention of the first-pass gut and liver metabolism and improved patient compliance. However, the stratum corneum is the main barrier that limits the diffusion of actives into the deeper layers of the skin. In order for actives to be delivered into/through the skin, many techniques have been proposed including the use of skin penetrations, which is the simplest way. In our group, a variety of compounds have been investigated such as volatile oils (as skin penetration enhancers), cosmetics (e.g. skin lightening agents, antioxidants and sunscreens) and drugs (e.g. NSAIDs and antifungal drugs). Both traditional and novel formulations (e.g. liposomes, microemulsions, nanoemulsions and solid lipid nanoparticles) have been developed as carrier vehicles for the actives. The study method focuses on the in vitro experiments. The main investigation consists of the release characteristics, the skin penetration and the skin retention of the actives. The development of safe and effective topical/transdermal delivery vehicles is our major research interests.

 

Research staff
• Assoc. Prof. Dr. Prapaporn Boonme, Department of Pharmaceutical Technology
• Assist. Prof. Dr. Sarunyoo Songkro, Department of Pharmaceutical Technology

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Faculty of Pharmaceutical Sciences, Prince of Songkla University
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