Vimon Tantishaiyakul, Ph.D.


Vimon Tantishaiyakul, Ph.D.

Born : 1956
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Academic rank : Professor

Education : 
1980 B.Sc. in Pharm Chulalongkorn University, Thailand
1985 M. Sc. in Pharmaceutical Chemistry Chulalongkorn University, Thailand
1990 Ph.D. Pharmacy (Medicinal Chemistry) The Ohio State University, USA

Scientific interest :
Organic synthesis / formulation development to enhance solubility / permeability properties, Cell culture/biotechnology for characterization of permeability property, chemometric analysis, development of polymer and materials for drug delivery system

Journal articles :

  • Hirun, N., Tantishaiyakul, V., Sangfai, T., Boonlai, W., Soontaranon, S. and Rugmai, S. The effect of poly(acrylic acid) on temperature-dependent behaviors and structural evolution of poloxamer 407. Polym. Int. [In Press]
  • Boonrat, O., Tantishaiyakul, V., Hirun, N., Rugmai, S. and Soontaranon, S. Structural characterization using SAXS and rheological behaviors of pluronic F127 and methylcellulose blends. Polymer Bulletin, 78(3):1175-1187, 2021.
  • Ouiyangkul, P., Saithong, S. and Tantishaiyakul, V. Syntheses and crystal structures of hydrated and anhydrous 1:2 cocrystals of oxyresveratrol and zwitterionic proline. Acta Cryst. (76):1528-1534, 2020.
  • Ouiyangkul, P., Tantishaiyakul, V. and Hirun, N. Exploring potential coformers for oxyresveratrol using principal component analysis. Int. J. Pharm., 587:119630, 2020.
  • Hirun, N., Tantishaiyakul, V., Sangfai, T., Ouiyangkul, P. and Li, L. In situ mucoadhesive hydrogel based on methylcellulose/xyloglucan for periodontitis. J. Sol-Gel Sci. Technol., 89(2):531-542, 2019.
  • Tantishaiyakul, V., Ouiyangkul, P., Wajasat, M., Pawisat, T., Hirun, N. and Sangfai, T. A Supramolecular gel based on 12-Hydroxystearic acid/virgin coconut oil for injectable drug delivery. Eur. J. Lipid Sci. Technol., 120(10):1800178, 2018.
  • Boonlai, W., Tantishaiyakul, V., Hirun, N., Sangfai, T. and Suknuntha, K. Thermosensitive poloxamer 407/poly(acrylic acid) hydrogels with potential application as injectable drug delivery system. AAPS PharmSciTech, 19(5):2103-2117, 2018.
  • Kongtaworn, N. Hirun, N., Tantishaiyakul, V., Rungrotmongkol, T. and Dokmaisrijan, S. Molecular Aggregation of Four Modified Xyloglucan Models in Aqueous Solution. Chiang Mai J. Sci, 45(5):2201 - 2210, 2018.
  • Rangabhatla, A.S.L., Tantishaiyakul, V., Boonrat, O., Hirun, N. and Ouiyangkul, P. Novel in situ mucoadhesive gels based on Pluronic F127 and xyloglucan containing metronidazole for treatment of periodontal disease. Iran Polym. J., 26(11):851-859, 2017.
  • Boonlai, W., Tantishaiyakul, V., Hirun, N., Phaisana, S. and Uma, T. The effect of the preservative methylparaben on the thermoresponsive gelation behavior of aqueous solutions of poloxamer 407. J. Mol. Liq., 240:622-629, 2017.
  • Sangfai, T., Tantishaiyakul, V., Hirun, N. and Li, L. Microphase Separation and Gelation of Methylcellulose in the Presence of Gallic Acid and NaCl as an In Situ Gel-Forming Drug Delivery System. AAPS PharmSciTech 18(3):605-616, 2017.
  • Sangfai, T., Dong, F., Tantishaiyakul, V., Jandt, K.D., Lüdecke, C., Boonrat, O. and Hirun, N. Layer-by-layer gelatin/chitosan polyelectrolyte coated nanoparticles on Ti implants for prevention of implant-associated infections. eXPRESS Polymer Letters 11(1):73.82, 2017.
  • Hirun, N., Tantishaiyakul, V., Sangfai, T., Rugmai, S. and Soontaranon, S. Nano-structure, phase transition and morphology of gallic acid and xyloglucan hydrogel. Polymer Bulletin, 73(8):2211-2226, 2016.
  • Rangabhatla, A.S., Tantishaiyakul, V., Oungbho, K. and Boonrat, O. Fabrication of pluronic and methylcellulose for etidronate delivery and their application for osteogenesis. International Journal of Pharmaceutics, 499(1-2):110-118, 2016
  • Rangabhatla, A., Tantishaiyakul, V. and Oungbho, K. Etidronate Loaded Gelatin Nanoparticles by Nanoprecipitation. Latin American Journal of Pharmacy, 34(8): 1684-1687, 2015.
  • Sangfai, T., Tantishaiyakul, V., Hirun, N. and Li, L. Preparation and characterization of K-carrageenan and xyloglucan blends for sustained release of a hydrophilic drug. Polymer Bulletin, 72(7): 1647-1661,2015.
  • Hirun, N., Sangfai, T. and Tantishaiyakul, V. Characterization of freeze-dried gallic acid/xyloglucan. Drug Development and Industrial Pharmacy, 41(2): 194-200, 2015.
  • Klaewklod, A., Tantishaiyakul, V., Hirun, N., Sangfai, T. and Li, L. Characterization of supramolecular gels based on b-cyclodextrin and polyethyleneglycol and their potential use for topical drug delivery. Materials Science and Engineering C, 50: 242-250, 2015.
  • Tantishaiyakul, V., Dokmaisrijan, S., Sangfai, T., Hirun, N., Li, L., Juntarapet, S. and Suknuntha, K. Investigation of the efficiency of gelation of melamine with thepositional isomers of aminobenzoic acid. Colloid Surface A., 446: 118-126, 2014.
  • Dokmaisrijan, S., Payaka, A., Tantishaiyakul, V., Chairat, M., Nimmanpipug, P. andLee, V.S. Conformations and spectroscopic properties of laccaic acid A in the gas phase and in implicit water. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 105: 125-134, 2013.
  • Tantishaiyakul, V., Suknuntha, K., Saithong, S. and Pakawatchai, C. Glabridin. Acta Cryst, E68:o3501, 2012.
  • Hirun, N., Bao, H., Li, L., Deen, GR. and Tantishaiyakul, V. Micro-DSC, rheological and NMR investigations of the gelation of gallic acid and xyloglucan. Soft Matter, 8: 3258-3268, 2012.
  • Hirun, N., Rugmai, S., Sangfai, T. and Tantishaiyakul, V. SAXS and ATR-FTIR studies on EBT-TSX mixtures in their sol-gel phases. International Journal of Biological Macromolecules, 51: 423-430, 2012.
  • Suknuntha, K., Jones, DS. and Tantishaiyakul, V. Properties of felodipine-poly(vinylpyrrolidone) solid dispersion films and the impact of solvents. ScienceAsia, 38(1): 188-195, 2012.
  • Hirun, N., Dokmaisrijan, S. and Tantishaiyakul, V. Experimental FTIR and theoretical studies of gallic acid-acetonitrile clusters. Spectrochim Acta A Mol Biomol Spectrosc, 86: 93-100, 2012.
  • Hirun, N., Saithong, S., Pakawatchai, C. and Tantishaiyakul, V. 3,4,5-Trihydroxybenzoic acid. Acta Crystallographica Section E-Structure Reports Online, 67: O787-U1528, 2011.
  • Suknuntha, K., Tantishaiyakul, V., Worakul, N. and Taweepreda, W. Characterization of muco- and bioadhesive properties of chitosan, PVP, and chitosan/PVP blends and release of amoxicillin from alginate beads coated with chitosan/PVP. Drug Development And Industrial Pharmacy, 34(4): 408-418, 2011.
  • Tantishaiyakul, V., Suknuntha, K. and Vao-Soongnern, V. Characterization of Cimetidine-Piroxicam Coprecipitate Interaction Using Experimental Studies and Molecular Dynamic Simulations. AAPS PharmSciTech, 1(2): 952-958, 2010.
  • Hirun, N., Tantishaiyakul, V. and Pichayakorn, W. Effect of Eriochrome Black T on the gelatinization of xyloglucan investigated using rheological measurement and release behavior of Eriochrome Black T from xyloglucan gel matrices. Int. J. Pharmaceutics, 388(1-2): 196-201, 2010.
  • Tantishaiyakul, V., Songkro, S., Suknuntha, K., Permkum, P. and Pipatwarakul, P. Crystal Structure Transformations and Dissolution Studies of Cimetidine-Piroxicam Coprecipitates and Physical Mixtures. AAPS PharmSciTech, 10(3): 789-795, 2009.
  • Tantishaiyakul, V., Permkam, P. and Suknuntha, K. Use of drifts and PLS for the determination of polymorphs of piroxicam alone and in combination with pharmaceutical excipients: a technical note. AAPS PharmSciTech 9 (1), 2008. pp: 95-99.
  • Suknuntha, K., Tantishaiyakul, V., Vao-Soongnern, V., Espidel, Y. and Cosgrove, T. Molecular modeling simulation and experimental measurements to characterize chitosan and poly (vinyl pyrrolidone) blend interactions. Journal of Polymer Science, Part B: Polymer Physics 46 (12), 2008. pp: 1258-1264.
  • Tantishaiyakul, V., Worakul, N., Wongpoowarak, W. Prediction of solubility parameters using partial least aquare regression. Int. J. Pharm.,325 (1-2): 8-14, 2006.
  • Wiwattanawongsa, K., Tantishaiyakul, V., Lomlim, L., Rojanasakul, Y., Pinsuwan, S., Keawnopparat, S. Experimental and computation studies of epithelial transport of mefenamic acid ester prodrugs. Pharm. Res, 22 (5): 721-727, 2005.
  • Tantishaiyakul, V.,Wongpuwarak, W.Prediction of Pgp-ATPase interaction and rhodamine 123 efflux inhibitory activities of propafenone analogs using PLS statistics.J. of Molec.Struc: THEOCHEM. 718 (1-3): 183-189, 2005.
  • Tantishaiyakul V. Prediction of the aqueous solubility of benzylamine salts using QSPR model. J Pharm Biomed Anal, 37:411-5, 2005.
  • Tantishaiyakul, V.; Phadoongsombut, N.; Wongpuwarak, W.; Thungtiwachgul, J.; Faroongsarng, D.; Wiwattanawongsa, K.; Rojanasakul, Y. ATR-FTIR characterization of transport properties of benzoic acid ion-pairs in silicone membranes Int. J. Pharm., 283, 111-116, 2004.
  • Tantishaiyakul, V. Prediction of aqueous solubility of organic salts of diclofenac using PLS and molecular modeling. Int. J. Pharm., 275: 133-139, 2004.
  • Ye, J.; Wang, L.; Zhang, X.; Tantishaiyakul, V.; Rojanasakul, Y. Inhibition of TNF-{alpha} Gene Expression and Bioactivity by Site-Specific Transcription Factor Binding Oligonucleotides. Am J Physiol Lung Cell Mol Physiol , 284(2): L386-94, 2003.
  • Tantishaiyakul, V.; Wiwattanawongsa, K.; Pinsuwan , S.; Kasiwong, S.; Phadoong-sombat, N.; Kaewnopparat, S.; Kaewnopparat, N.; Rojanasakul, Y. Characterization of mefenamic acid - guaiacol ester: stability and transport across Caco-2 cell monolayers. Pharm. Res., 19(7): 1014-1019, 2002.
  • Tantishaiyakul V. Prediction of Caco-2 cell permeability using partial least square multivariate analysis. Pharmazie, 56: 407-411, 2001
  • Ingkatawornwong, S.; Kaenopparat, N.; Tantishaiyakul V. Studies on Aging Piroxicam-polyvinylpyrrolidone Solid Dispersions. Pharmazie, 56: 227-230, 2001.
  • Tantishaiyakul, V.; Phadoongsombut, N.; Kamaung, S.; Wongwisansri, S.; Mathurod, P. Fourier transform infrared spectometric determination of paracetamol and ibuprofen in tablets. Pharmazie, 54: 111-114, 1999.
  • Tantishaiyakul, V.; Kaenopparat, N.; Ingkatawornwong, S. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. Int. J. Pharm., 181: 143-151, 1999.
  • Tantishaiyakul, V. Poeaknapo, C.; Sribun, P.; Sirisuppanon, K. Simultaneous determination of dextromethorphan HBr and bromhexine HCl in tablets by first-derivative spectrophotometry . J. Pharm. Biomed. Anal. , 17: 237-243, 1998.
  • Tantishaiyakul, V.; Chuchom, T. Fourier transform infrared spectrometric determination of benzyl alcohol and benzaldehyde . Thai J. Pharm. Sci. , 22: 73-79, 1998.
  • Tantishaiyakul, V.; Kaenopparat, N.; Ingkatawornwong, S. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone K-30. Int. J. Pharm., 143: 59-66, 1996.
  • Tantishaiyakul, V.; Oungbho, K.; Lerkiatbundit, S. Bioavailability of diclofenac sodium tablets marketed in Thailand Part I: in vitro study. Songklanakarin J. Sci. Technol., 15: 226-281, 1993.
  • Tantishaiyakul, V.; Wiwatthanawongsa, K.; Lerkiatbundit, S. Bioavailability of diclofenac sodium tablets marketed in Thailand Part II: in vivo study. Songklanakarin J. Sci. Technol., 15: 283-289, 1993.
  • Romstedt K.J.; Shin Y.; Shams G.; Doyle K.; Tantishaiyakul V.; Clark M.T.; Adejare A.; Hamada A.; Miller D.D.; Feller D.R.Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta, Biochemical Pharmacology, Volume 46, Issue 11: 2051-2059, 1993.
  • Markovich, K. M.; Tantishaiyakul, V.; Hamada, A.; Miller, D. D.; Romstedt, K. J.; Shams, G.; Shin. Y.; Feller, D.R. Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities. J. Med. Chem., 35: 466-479, 1992.
  • Venkataraman, B. V.; Sham, G.; Hamada, A.; Amemiya, Y.; Tantishaiyakul, V.; Hsu, F.; Fashempour, J.; Romstedt, K. J.; Miller, D. D.; Feller, D.R. Structure-activity studies of new imidazole on adrenoceptors of rat aorta and human platelets. Naunyn-Schmiedeberg's Arch. Pharmacol., 334: 454-463, 1991.
  • Feller D. R., Shams G. S., Venkataraman B. V., Romstedt K. J., Fashempour J. T., Tantishaiyakul V., Miller D. D. and Patil P. N. Alpha adrenergic activities of aromatic ring iodinated analogues of catecholimidazoline in blood vessels and platelets. European Journal of Pharmacology, 183: 993, 1990.
  • Tantishaiyakul V, Pummangura S, Chaichantipyuth CJ, Ma WW, Mclaughlin JL. Phebalosin from the bark of Micromelum minutum. J Nat Prod 1986;49:180-1.



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